Is ketogenic diet treatment hepatotoxic for children with intractable epilepsy?

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Is ketogenic diet treatment hepatotoxic for children with intractable epilepsy?

PURPOSE Long-term ketogenic diet (KD) treatment has been shown to induce liver steatosis and gallstone formation in some in vivo and clinical studies. The aim of this retrospective study was to evaluate the hepatic side effects of KD in epileptic children. METHOD A total of 141 patients (mean age: 7.1±4.1years [2-18 years], 45.4% girls), receiving KD at least one year for intractable epilepsy...

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Ketogenic diet for epilepsy treatment.

The ketogenic diet (KD), a high-fat, low-carbohydrate, and adequate-protein diet is an established, effective nonpharmacologic treatment option for intractable childhood epilepsy. The KD was developed in 1921 and even though it has been increasingly used worldwide in the past decade, many neurologists are not familiar with this therapeutic approach. In the past few years, alternative and more f...

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efficacy of the ketogenic diet as a therapy for intractable epilepsy in children

objective to determine the role of ketogenic diet in the treatment of intractable epilepsy in children. materials & methods sixty six consecutive children (1-16 years old) with intractable epilepsy whose seizure were not neurodegenerative nor febrile in origin were recruited. they received the ketogenic diet and we evaluated its effect on seizure frequency for 3 months. all these children had m...

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The ketogenic diet in children with epilepsy.

Children with epilepsy, especially those facing intractable seizures, experience a great impact on the quality of their lives. Effective treatment is essential, and although new anti-epileptic drugs have shown an improved profile of action, still a substantial number of children look for more efficacious ways of treatment that are far away from potential toxicity and ineffectiveness. The ketoge...

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Low-glycemic-index treatment: a liberalized ketogenic diet for treatment of intractable epilepsy.

The ketogenic diet is often effective for intractable epilepsy, but many patients have trouble complying with the strict regimen. The authors tested an alternative diet regimen, a low-glycemic-index treatment, with more liberal total carbohydrate intake but restricted to foods that produce relatively little increase in blood glucose (glycemic index < 50). Ten of 20 patients treated with this re...

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ژورنال

عنوان ژورنال: Seizure

سال: 2016

ISSN: 1059-1311

DOI: 10.1016/j.seizure.2016.10.024